HAP1 (Neuroan 1, HLP, HIP5, Huntingtin-Associated Protein 1, RP23-392I3.11, HAP-1, MGC31449)

Size

£642.00

SKU:: H1815-07C
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-QDAHSKRQQKQK, from the C Terminus of HAP1(NP_034534.1).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: Huntingtin is the protein product of the gene for Huntington’s disease (HD). HD is a neurodegenerative disorder caused by an expansion of polyglutamine repeats in the huntingtin gene. The HAP1 molecule was reported to bind to the amino terminal region of huntingtin, and enhanced binding correlated with expanded polyglutamine repeats, suggesting a role for HAP1 in the pathogenesis of HD. At least three HAP1 isoforms have been identified but others may exist. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.