G8602-75C
LGR7 (Relaxin Receptor 1, Leucine-rich Repeat-containing G-protein Coupled Receptor 7, Relaxin Family Peptide Receptor 1, RXFP1) (Not for Export EU)
Size
£537.00
- SKU:
- G8602-75C
- Purity:
- Serum.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- aa694-732 of human Relaxin receptor 1/LGR7. Species sequence homology: equine, bovine, canine, feline and primate
- Format:
- Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
- Extra Details:
- The relaxin receptor, LRG7, has recently been identified as the only human G-protein-coupled receptor to contain a low-density lipoprotein class-A (LDL-A) module. The mosaic protein contains an N-terminal low density lipoprotein (LDL) receptor cysteine-rich motif, a set of ten leucine-rich repeats and a seven transmembrane region with an intracellular C-terminus. The protein specifically binds human relaxins H1 and H2 with high affinity and thus stimulates adenylate cyclase activation, substrate adhesion, and chemo migratory capacity of mononuclear leukocytes. LGR7 is critical for mediating these biological responses by use of RNA interference lentiviral short hairpin constructs. The gene encoding for LRG7 is mapped to 4q32.1 region of human chromosome. The protein is commonly expressed in human brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:100 Immunohistochemistry: frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice