G-Protein Coupled Receptor 68 (GPR68, GPR12A, Ovarian Cancer G-protein Coupled Receptor 1, OGR-1, OGR1, Sphingosylphosphorylcholine Receptor)

Size

£806.00

SKU:: G8600-72B
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 17aa from N-terminal domain of human G Protein Coupled Receptor 68. Species Sequence Homology: mouse, monkey, rat, canine, hamster, porcine and rabbit
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Extra Details:: OGR1 is a seven pass transmembrane protein initially cloned from an ovarian cancer cell line. OGR1 has a wide expression, and selectively binds both protons and bioactive lipids. OGR1 functions as a proton-sensing G protein-coupled receptor stimulating inositol phosphate production and Ca2+ mobilisation. It is also a receptor for sphingophosphorylcholine and related lysolipids, which antagonise the proton-induced actions mediated by OGR1. OGR1 is also expressed early during osteoclastogenesis and plays a role in osteoclast differentiation. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 5-10ug/ml. Requires antigen retrieval using sodium citrate pH6.0 heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Positive Control: Testis Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice