G8577-50
Golgi Marker, 58K
Size
£665.00
- SKU:
- G8577-50
- Purity:
- Ascites
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Golgi 58K protein from rat liver. Cellular Localization: Cytoplasmic and Golgi apparatus
- Clone:
- 58K-9 (3C140)
- Format:
- Supplied as a liquid, 15mM sodium azide.
- Extra Details:
- 58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. Applications: Suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:5000-1:10,000 Immunofluorescence (IC): 1:50-1;100 Optimal dilutions to be determined by the researcher. Positive Control: Western Blot (Colometric): Rat liver. Indirect Immunofluorescence: CHO cells Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice