G8170-30A
Glycogen Synthase, phosphorylated (Ser640)
Size
£914.00
- SKU:
- G8170-30A
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic phospho peptide corresponding to a S641 region of human Glycogen Synthase, conjugated to KLH.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. No stabilizing proteins added.
- Extra Details:
- Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephosphorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phosphorylate muscle glycogen synthase. Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilutions: ELISA: 1:20,000 - 1:60,000 Western Blot: 1:1000-1:10,000 Immunohistochemistry (paraffin): 1:1000-1:5000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice