G3500-19-ML650
GluR3 (Glutamate Receptor) (MaxLight 650)
Size
£1,023.00
- SKU:
- G3500-19-ML650
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Fusion protein encompassing the N-terminal region of rat GluR3.
- Clone:
- 6A90
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight™650.
- Extra Details:
- MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Regulation of fast excitatory synaptic neurotransmission is mediated primarily by ionotropic glutamate receptors (iGluR); ligand-gated cation (principally Ca2+) channels found on postsynaptic neurons throughout the central nervous system. Pharmacologic properties and amino acid sequence similarities allow classification of iGluR into three main subfamilies named for their principal agonists: 1) NMDA (N-methyl-D-aspartate) receptors, and the two non-NMDA receptor subfamilies, 2) AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors and 3) kainate. iGluR are oligomeric protein complexes comprised of 4 or 5 subunits, with the subunit composition determining specific electrophysiological properties. All NMDA receptors contain one NR1 subunit (encoded by a single gene producing 8 identified splice variants) and several NR2 subunits (four genes, A-D). AMPA and kainate receptors are comprised of subunits GluR1-4 (AMPA) and subunits GluR5-7, KA1 and KA2 (kainate). Applications: Suitable for use in Western Blot, Immunocytochemistry, Immunofluorescence and Electron Microscopy. Other applications have not been tested. Recommended Dilutons: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice