G2040-39E

Glucagon-like Peptide 2 Receptor (GLP2R)

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£754.00

SKU:: G2040-39E
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: 4°C (-20°C Glycerol)
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: 18aa synthetic peptide of human GLP2R. Epitope located at the N terminus, extracellular. Conjugated to KLH.
Format:: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 40% glycerol.
Extra Details:: Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration. GLP2 Receptor, a 550aa protein in rat, 553aa in human (chr 17p13.3), serves as receptor for GLP2. The activity of this receptor is mediated by G proteins which activate the adenylyl cyclase. GLP2 Receptor is mainly expressed in gut, and closely related to the receptor for GLP1. Applications: Suitable for use in Western Blot and ELISA . Other applications not tested. Recommended Dilutions: Western Blot: 1-10ug/ml, using Chemiluminescence technique. ELISA: 1:10,000-1:100,000 use 50-100ng/ml control peptide/well. Optimal dilutions to be determined by researcher. Control Peptide: G2040-39F Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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