G2034-45D

Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B)

Size

£473.00

SKU:: G2034-45D
Molecular Weight:: 494.5
Purity:: > 95% by HPLC
Storage Conditions:: -20°C, protect from light
Supplier:: United States Biological
CAS Number:: 77879-90-4
Extra Details:: Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactiviated crosslinkers of DNA to histones. Purity: > 95% by HPLC Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, O-Deacetyl-ravidomycin