F9300
FXR (Farnesoid X-activated Receptor, HRR-1, BAR, RIP14, NR1H4)
Size
£863.00
- SKU:
- F9300
- Purity:
- Purified by ammonium sulfate precipitation.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to aa2-126 from human FXR.
- Clone:
- 5L1
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Extra Details:
- Farnesoid X-activated receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of the orphan nuclear receptor family. FXR is expressed in the liver, intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and IBABP (ileal bile acid binding protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR. FXR is shown to be transcriptionally activated by farnesol metabolites such as farnesol itself and juvenile hormone III. FXR binds to DNA only as a heterodimer with RXR. Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Direct ELISA: 0.2ug/ml Western Blot: 1ug/ml Immunohistochemistry: 20-40ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice