F9049-98D
FOXP1 (Forkhead Box P1, 12CC4, Forkhead Related Protein-like B, hFKH1B, Glutamine Rich Factor 1, HSPC215, QRF1)
Size
£825.00
- SKU:
- F9049-98D
- Purity:
- Purified by affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Linear peptide corresponding to the C-terminus of human FOXP1 (KLH). Species sequence homology: bovine and rhesus macaque.
- Format:
- Supplied as a liquid in PBS, 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
- Extra Details:
- Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development. Applications: Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Immunohistochemistry: 1:300 Immunocytochemistry: 1:500 Optimal dilutions to be determined by the researcher. Positive Control: linear peptide corresponding to the C-terminus of human FOXP1. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice