FLCN, CT (Folliculin, Birt-Hogg-Dube Syndrome Protein, BHD Skin Lesion Fibrofolliculoma Protein, BHD)

Size

£696.00

SKU:: F5730-01
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 505-534 in the C-terminal region of human FLCN, UniProt Accession #Q8NFG4. Species sequence homology: mouse, rat, bovine
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Applications: Suitable for use in ELISA, Immunohistochemistry, Indirect Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Indirect Flow Cytometry: 1:10-1:50 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.