FLIP-L, CT (FLICE Inhibitory Protein)

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£678.00

SKU:: F4550-01
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to the C-terminus of human FLIP-L. Epitope: last 50aa
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: FLICE-inhibitory proteins (FLIP) are widely expressed apoptosis regulator proteins. FLIPs may function as a crucial link between cell survival and cell death pathways in mammalian cells. At least 14 isoforms of FLIP have been defined arising from alternative splicing. The long form FLIP-L contains a domain similar to those found in caspases. FLIP was cloned independently in a number of laboratories and is also known as Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP has two death effector domains (DEDs) and a caspase-like domain. It interacts with FADD and caspase-8 and -10, potently inhibiting apoptosis by all known death receptors. FLIP exists in a short form (FLIPS) and a long form (FLIPL). Applications: Suitable for use in ELISA, Immunocytochemistry, Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Immunocytochemistry: 10ug/ml Immunofluorescence: 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice