F4522-01
FK-506 (Fujimycin, Tacrolimus)
Size
£373.00
- SKU:
- F4522-01
- Molecular Weight:
- 804.02
- Purity:
- ≥99% (HPLC, TLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 104987-11-3
- Format:
- Off-white to white powder
- Extra Details:
- FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Synonyms: Advagraf; FR 900506; Fujimycin; L 679934; Prograf; Protopic; TacroBell; Tacrolimus; Tsukubaenolide; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone CAS No: 104987-11-3 Molecular Formula: C44H69NO12 Molecular Weight: 804.02 Appearance: Off-white to white powder Purity: ≥99% (HPLC, TLC) Solubility: Soluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice