F4305-08-BIOTIN

Fibroblast Growth Factor Receptor beta (Flg, FGFRb, FGFR1) (Biotin)

Size

£1,055.00

SKU:: F4305-08-BIOTIN
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Bovine Fibroblast Growth Factor Receptor beta puriﬁed from Coronary Venular Endothelial Cells (CVEC).
Clone:: 3G150
Format:: Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Biotin.
Extra Details:: Currently four FGF receptors have been identiﬁed, FGFR-1 (ﬂg), FGFR-2 (bek), FGFR-3, and FGFR-4. FGFR-1 and FGFR-2 exist in multiple forms that represent alternative splicing of their respective genes. The FGF Receptor consists of three immunoglobulin-like domains, a transmembrane region and a cytosolic tyrosine kinase domain which is activated by ligand binding. FGFs play important roles in angiogenesis, wound healing, tumorigenesis and metastasis. The FGF family consists of 7 members, FGF-1 through FGF-7. FGFs 1 and 2 are also known as basic FGF (bFGF) and acidic FGF (aFGF), respectively. It is known that multiple FGFs can bind and activate FGFR-1, FGFR-2, and FGFR-3. Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Paraffin sections Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0/Ag14 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.

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