F0019-65F

Fas Ligand, Human (FASL) Control Peptide

Size

£576.00

SKU:: F0019-65F
Purity:: Purified ≥95%
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied in SDS-PAGE sample buffer (reduced
Extra Details:: 13-aa peptide from human FASL . Apoptosis occurs not only during programmed cell death, but also during the death process induced by some cytotoxic T cells. A protein ligand, FASL, was identified that triggers cell death by binding to the cell surface receptor variously known as FAS or APT1 family of receptors that includes the 2 tumor necrosis factor (TNF) receptors. The FAS antigen is expressed not only in the cells of the immune system but also in the liver, lung, ovary, and heart, where its function is unclear. FAS ligand/FASL (human 281-aa, ~ 32kD, chromosome 1q23) is a type II transmembrane protein that belongs to the tumor necrosis factor family. FASL is expressed in activated splenocytes and thymocytes, consistent with its involvement in T-cell-mediated. FASL is proteolytically cleaved at the cell surface and relased into the extracellualr fluid. FASL is alternative spliced into two forms: Defects in TNFSF6 are a cause of autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome (CSS), a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.