F0015-01

Factor VII (F.VII, Stable Factor, Proconvertin)

Size

£588.00

SKU:: F0015-01
Purity:: Purified by gel filtration and ion exchange chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rat
Immunogen:: Purified Factor VII.
Clone:: 7H80
Format:: Supplied as a liquid in 50% glycerol, H2O.
Extra Details:: Coagulation factor VII is synthesized in the liver and circulates in the plasma where it binds to tissue factor (TF) and is rapidly converted into VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and also has important coagulation-independent functions such as angiogenesis. The predominant splicing variant of Factor VII in normal liver corresponds to the 444 amino acid precursor. After cleavage of a signal peptide (residues 1 to 38), the mature chain can be further processed into the light chain (residues 39 to 190) and the heavy chain (residues 191 to 444). Applications: Suitable for ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: Recombinant Western Blot: Recombinant Factor VII or Factor VIIa and native Factor VII (Non-reduced) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.