Everolimus

Size

£165.00

SKU:: E9002-35
Molecular Weight:: 958.22
Purity:: ≥98% (HPLC, TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 159351-69-6
Format:: White to off-white powder
Extra Details:: Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that can prevent allograft rejection, and may demonstrate activity in both the prevention and treatment of PTLDs in transplant patients. Synonyms: Afinitor, Certican, RAD-001, Zortress; 40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; RAD; RAD 001; SDZ-RAD; XIENCE V CAS No: 159351-69-6 Molecular Formula: C53H83NO14•xH2O Molecular Weight: 958.22 Purity: ≥98% (HPLC, TLC) Appearance: White to off-white powder Elemental Analysis: Calculated: C 65.51%; H 8.78%; N 1.43% Melting Point: 90-115°C Cis-Isomer (HPLC): ≤15% Solubility: Soluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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