E3452-75

Erlotinib Hydrochloride

Size

£160.00

SKU:: E3452-75
Molecular Weight:: 429.9
Purity:: ≥99% (HPLC, TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 183319-69-9
Format:: White to off-white powder
Extra Details:: Inhibitor of the epidermal growth factor receptor tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. Erlotinib binds reversibly to the ATP binding site of the receptor. Synonyms: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline Hydrochloride; [6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine Hydrochloride; CP 358774; OSI 774; Tarceva CAS No: 183319-69-9 Molecular Formula: C22H23N3O4•HCl Molecular Weight: 429.90 Appearance: White to off-white powder Purity: ≥99% (HPLC, TLC) Solubility: Soluble in DMSO at 18mg/ml with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis (Calculated): C: 61.46% H: 5.63% Cl: 8.25% N: 9.77% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.