Epothilone D (KOS 862)

Size

£558.00

SKU:: E3428-75C
Molecular Weight:: 477.66
Purity:: ≥99%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 189453-10-9
Format:: White to off-white powder
Extra Details:: Epothilones are polyketid. Potent microtubule stabilizer. Epothilone D is a more potent microtubule stabilizer in vitro than epothilone A or B. In vitro, Epothilone D showed potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. It also showed definite advantage over paclitaxel in drug-resistant cell lines, and retained its cytotoxicity against a multidrug resistant cell line over-expressing P-glycoprotein. Synonyms: 12,13-Deoxyepothilone B, EpoA; (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; KOS 862 CAS No: 189453-10-9 Molecular Formula: C27H41NO5S Molecular Weight: 477.66 Appearance: White to off-white powder Purity: ≥99% Melting Point: 63-66°C Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.