E3373-05C
EphB4 (Ephrin type-B receptor 4, HTK, MYK1, Tyro11, TYRO11)
Size
£748.00
- SKU:
- E3373-05C
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to the C-terminal sequence of the human EphB4 receptor.
- Clone:
- 6A77
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
- Extra Details:
- Eph receptors belong to a family of receptor tyrosine kinases. Both ephrins, the ligands for Eph receptors, and Eph receptors are broadly expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. The interaction of ephrins with the appropriate Eph receptor(s) has been implicated in a wide spectrum of functions in vertebrate morphogenesis, including the accurate migration of embryonic cells, formation of boundaries between structures (i.e. rhombomeres and somites), and the control of cytoskeletal changes which dictate cellular shape and adhesion during development. The EphB4 receptor, also known as Htk, Myk1, Tyro11 and Mdk2, was originally identified in CD34+ cells in the bone marrow and has since also been found in erythroid progenitor cells. The interaction between the EphB4 receptor and its ligand, ephrin B2, is critical for embryonic capillary morphogenesis. Upregulation of the EphB4 receptor has been observed in colon carcinoma, and in endometrial cancer4. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilution: ELISA: 0.1-1ug/ml Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice