E3373-05C-APC
EphB4 (Ephrin type-B receptor 4, HTK, MYK1, Tyro11, TYRO11) (APC)
Size
£1,004.00
- SKU:
- E3373-05C-APC
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to the C-terminal sequence of the human EphB4 receptor.
- Clone:
- 6A77
- Format:
- Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
- Extra Details:
- Eph receptors belong to a family of receptor tyrosine kinases. Both ephrins, the ligands for Eph receptors, and Eph receptors are broadly expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. The interaction of ephrins with the appropriate Eph receptor(s) has been implicated in a wide spectrum of functions in vertebrate morphogenesis, including the accurate migration of embryonic cells, formation of boundaries between structures (i.e. rhombomeres and somites), and the control of cytoskeletal changes which dictate cellular shape and adhesion during development. The EphB4 receptor, also known as Htk, Myk1, Tyro11 and Mdk2, was originally identified in CD34+ cells in the bone marrow and has since also been found in erythroid progenitor cells. The interaction between the EphB4 receptor and its ligand, ephrin B2, is critical for embryonic capillary morphogenesis. Upregulation of the EphB4 receptor has been observed in colon carcinoma, and in endometrial cancer4. Applications: Suitable for use in FLISA and Western Blot. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice