E3365-03
EphA3 Receptor (Ephrin A3 Receptor)
Size
£698.00
- SKU:
- E3365-03
- Purity:
- Purified by Protein A affinity chromatography
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Synthetic peptide corresponding to the C-terminal region of the human EphA3 receptor.
- Clone:
- 6A71
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
- Extra Details:
- Eph receptors belong to a family of receptor tyrosine kinases. Both ephrins, the ligands for Eph receptors, and Eph receptors are broadly expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. The interaction of ephrins with the appropriate Eph receptor(s) has been implicated in a wide spectrum of functions in vertebrate morphogenesis, including the accurate migration of embryonic cells, formation of boundaries between structures (i.e. rhombomeres and somites), and the control of cytoskeletal changes which dictate cellular shape and adhesion during development. EphA3 receptor, also known as Cek4, Mek4, Hek, Tyro4 and Hek4, is thought to repel receptor positive myoblasts and axons away from the limb bud and towards the body wall. EphA3 receptor is involved in targeting of the retinotectal projection and the organization of the retinotectal pathway. Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications have not been tested. Recommended Dilutions: ELISA (Immunogen): 0.1-1ug/ml Western Blot (Rat): 1-3ug/ml, detects a band at ~110kD. Immunoprecipitation (Rat): 5-10ug Optimal dilutions to be determined by the researcher. Positive Control: Human EphA3 receptor transfected HEK-293 cell lysate. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice