E3222-26
Enniatin A (Lateritin I)
Size
£403.00
- SKU:
- E3222-26
- Molecular Weight:
- 681.9
- Purity:
- ≥98% by HPLC
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 2503-13-1
- Format:
- White to off-white solid
- Extra Details:
- Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A is one of four major analogs of the enniatin complex and has previously not been available for investigation. • Cyclohexadepsipeptide mycotoxin. One of four major analogs in the enniatin complex. Commonly found food contaminant in cereals and their products. • Ionophore antibiotic. Incorporation into the cell membrane forms dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. • Anticancer compound. Triggers apoptosis in several cancer cell lines. Leads to loss of mitochondrial membrane potential and cell cycle arrest. • Moderate inhibitor of ACAT (acylcoenzyme A:cholesterolacyl transferase). • Shown to have a variety of other biological activities such as antifungal, anthelmintic, insecticidal, immunomodulatory and phytotoxic activity. Source: Fusarium sp. MST-FP1765 Synonyms: Lateritin I; Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl]; N-(D-2-Hydroxy-3-methylbutyryl)-N-methyl-Isoleucine Trimol. Cyclic Ester; 1,7,13-Trioxa-4,10,16-triazacyclooctadecane Cyclic Peptide Deriv.;_x000B_Cyclo(D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl-D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl-D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl) CAS No: 2503-13-1 Molecular Formula: C₃₆H₆₃N₃O₉ Molecular Weight: 681.9 Appearance: White to off-white solid Purity: ≥98% by HPLC Source: Enniati Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at 4°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Protect from light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice