E2249-80
Elongator Protein 1 (ELP1, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, Kinase Complex-associated Protein, IKBKAP, DYS, ELP1, FD, FLJ12497, IKAP, IKI3, P150, TOT1, DKFZP781H1425)
Size
£745.00
- SKU:
- E2249-80
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Elongator complex (130kD)
- Clone:
- 7E8/G10
- Format:
- Supplied as a liquid in PBS, pH 7.2.
- Extra Details:
- Its function is not clear, but it has been demonstrated that the human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. IKBKAP. IKBKAP was originally described as a scaffold protein of the IKK complex involved in NF-kB activation, but this role has since been disputed. IKBKAP is a component of the RNA polymerase II elongator complex which has histone acetyltransferase activity and is involved in transcriptional elongation. Gene defects are a cause of familial dysautonomia, also known as Riley-Day syndrome. Affected individuals show a variety of symptoms such as decreased sensitivity to pain and temperature, cardiovascular instability, pneumonia and gastrointestinal dysfunction. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice