Doramectin

Size

£327.00

SKU:: D9025-01
Molecular Weight:: 899.1
Purity:: ~95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 117704-25-3
Format:: Supplied as a white solid.
Extra Details:: Doramectin is a biosynthetic avermectin derived from a mutant of the original Streptomyces avermitilis strain supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite. Source: Doramectin from Streptomyces sp., biosynthetic. Molecular Weight: ~899.1 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.