D3935-33K

DNA Polymerase, eta (POLH, RAD30 Homolog A, Xeroderma Pigmentosum Variant Type Protein, RAD30, RAD30A, XPV)

Size

£685.00

SKU:: D3935-33K
Purity:: Purified.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: POLH (NP_006493.1, 1-713aa) full-length human protein.
Format:: Supplied as a liquid in PBS, pH 7.2.
Extra Details:: DNA polymerase eta is specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. It also plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. It targets POLI to replication foci. Applications: Suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence. Other applications not tested. Recommended Dilution: Immunocytochemistry/Immunofluorescence: 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.