D3570-04A

Ivermectin B1b

Size

£431.00

SKU:: D3570-04A
Molecular Weight:: 861.1
Purity:: ≥95% by HPLC
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 70209-81-3
Format:: Supplied as a white solid
Extra Details:: Ivermectin B1b is the minor component (>20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro tests have found the B1b (25-iso-propyl) analogue to be slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis and also a more sensitive probe for ivermectin resistance. Purity: ≥95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.