N-Desmethyl Imatinib (CGP-74588)

Size

£473.00

SKU:: D3220-88R
Molecular Weight:: 479.58
Purity:: ~90%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 404844-02-6
Format:: Supplied as an off-white to pale yellow solid.
Extra Details:: A metabolite of Imatinib, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Synonym: N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide Solubility: Chloroform Melting Point: 181-183ºC (dec.) Method for Determining Identity: Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: SiO2: Dichloromethane: Methanol: NH4OH; 4: 1: 0.1; Visualized with UV and ninhydrin; Rf=0.25. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.