D1038-08A

DAND5 (DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, GREM3, Gremlin-3, SP1)

Size

£1,017.00

SKU:: D1038-08A
Purity:: Purified by Protein G affinity chromatography from hybridoma culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to Arg23-Ala189 from human DAND5, expressed in E. coli.
Clone:: 9L820
Format:: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
Extra Details:: COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN, Gremlin, PRDC, and Cerberus. COCO binds and inhibits Xnr1, BMP-4, Activin, and Wnt8. It is implicated in gastrulation and embryonic left-right axis formation. Human COCO shares 60% and 24% aa sequence identity with mouse and Xenopus COCO, respectively. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 2-8ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.