CYPB (Peptidyl-prolyl cis-trans Isomerase B, PPIase B, CYP-S1, Cyclophilin B, Rotamase B, S-cyclophilin, SCYLP, PPIB)

Size

£601.00

SKU:: C8855-01D
Application:: WB
Purity:: Purified by Protein G affinity chromatography
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa100-228 of human CYPB. Species Sequence Homology: chicken, 84%
Format:: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Extra Details:: Peptidylprolyl isomerase B, also known as Cyclophilin B and PPIB, is a 216aa containing enzyme with peptidyl-prolyl cis-trans isomerase (PPIase) activity and is associated with the secretory pathways and released in biological fluids. It belongs to the cyclophilin-type PPIase family and PPIase B subfamily with a PPIase cyclophilin-type domain and is usually located in the lumen of endoplasmic reticulum and melanosomes. PPIases accelerate the folding of proteins and are known to catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This cyclosporine-binding protein can also bind to cells derived from T- and B-lymphocytes, and is inhibited by the immunosuppressive drug cyclosporin A (CsA) and is hence an important element in the study of CsA-mediated immunosuppression. Reports also suggest that PPIB is an important component of the HCV replication machinery, acting as a stimulatory regulator of NS5B and could be a possible target for antiviral therapy. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice