C7947-97

CTDSPL (CTD Small Phosphatase-like Protein, CTDSP-like, Carboxy-terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 3, NIF-like Protein, Nuclear LIM Interactor-interacting Factor 1, NLI-interacting Factor 1, Protein YA22, hYA22, RBSP3, Small C-terminal Domain Phosphatase 3, SCP3, Small CTD Phosphatase 3, C3orf8, NIF1, NIFL, SCP3, YA22)

Size

£448.00

SKU:: C7947-97
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to QCNVSLKKQRSRS, from CTDSPL, at the internal region of the protein (NP_001008393.1, NP_005799.2).
Format:: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Extra Details:: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.