Connexin 26 (CX26, Gap Junction Beta 2 Protein, CXB-2)

Size

£735.00

SKU:: C7853-04
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 13aa derived from the C-terminus of the mouse Connexin 26 protein. This mouse sequence differs from the rat sequence by a single aa and from the human sequence by two (non-consecutive) amino acids.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Extra Details:: Intercellular communication through gap junctions plays an important role in a variety of cellular processes including homeostasis, morphogenesis, cell differentiation, and growth control. Gap junctions are transmembrane channels that serve to directly link neighboring cells by mediating the exchange of low-MW <1200 kD metabolites, ions, and second messengers. Gap junctions are formed by the interaction of hemichannels (connexons) on adjacent cells. The connexon itself is composed of a hexameric assembly of connexin proteins. Connexins are highly homologous proteins encoded by a multigene family. The connexins exhibit similar structural features, which include a cytoplasmic amino terminal region, four transmembrane domains, two extracellular loops, and a carboxy-terminal cytoplasmic tail of varying length. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA (Immunogen): 0.1-1.0ug/ml Immunohistochemistry (Rat): 10-20ug/ml Western Blot (Mouse and Rat): 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice