C7852-20
Concanamycin A (Olimycin, Folimycin, Antibiotic TAN 1323B) 95+%
Size
£486.00
- SKU:
- C7852-20
- Molecular Weight:
- 866.09
- Purity:
- ≥95% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 80890-47-7
- Format:
- White lyophilized powder
- Extra Details:
- Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp. It has has been shown to act as a potent and specific vacuolar-APTase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins. Source: Streptomyces sp. Synonyms: Folimycin, Antibiotic TAN 1323B; (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one CAS No: 80890-47-7 Molecular Formula: C46H75NO14 Molecular Weight: 866.09 Appearance: White lyophilized powder Purity: ≥95% (HPLC) Related to: Bafilomycin A1, Bafilomycin B1, Bafilomycin C1 Solubility: Ethanol, Methanol, DMF, DMSO Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice