C7507

Colchicine ((-)-Colchicine)

Size

£293.00

SKU:: C7507
Molecular Weight:: 399.4
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 64-86-8
Extra Details:: Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines. Synonyms: (-)-Colchicine; NSC 757; EINECS 200-598-5, N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen- 7-yl]acetamide CAS Number: 64-86-8 Source: Colchicum autumnale Molecular Weight: 399.4 Molecular Formula: C22H25NO6 Purity (HPLC): Content of Colchicine: 94-101% (HPLC) Chromatographic Purity: ≥95% (HPLC) Appearance: Pale yellow to green crystalline powder Melting Point: 155-157°C Optical Rotation: [a]D20 = -240 to -250º (C=1 in EtOH) Water (KF): ≤2% E. coli, Salmonella, S. aureus: Negative Yeast and Mold: ≤100cfu/g Microbial Count: ≤1000cfu/g (TPC) Related Substances: Total Impurity: ≤5% Residual Solvents: Limit of Colchicine: Complies Limit of Ethylacetate: ≤8% Chloroform: ≤100ppm Methylene chloride: ≤ 600ppm Methanol: ≤ 3000ppm Hexane: ≤290 ppm Solubility: 100% ethanol (>100mg/ml), DMSO (>100mg/ml), water or DMF Storage and Stability: Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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