2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907)

Size

£288.00

SKU:: C5029-18
Molecular Weight:: 277.66
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 313516-66-4
Extra Details:: A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85uM and 1.8uM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. Alternate Names: T0070907 CAS Number: 313516-66-4 Molecular Weight: 277.66 Appearance: Supplied as a light orange solid. Molecular Formula: C₁₂H₈ClN₃O₃ Solubility: DMSO (Slightly), Methanol (Slightly) Melting Point: >184°C (dec.) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.