C2589-88

CEBP alpha, bZIP Region, Recombinant, Human, aa270-358, His-Tag (CCAAT Enhancer Binding Protein, alpha)

Size

£364.00

SKU:: C2589-88
Molecular Weight:: 14.5
Purity:: ≥ 95% by SDS PAGE; Purified by ion-exchange chromatography and FPLC gel-filtration chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M sodium chloride, 5mM beta-Mercaptoethanol.
Extra Details:: CCAAT/enhancer binding protein (C/EBP) alpha is a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins, C/EBP alpha, beta, gamma, delta, that form homodimers and that form heterodimers with each other. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein; a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBPs differ significantly in their physiological functions and in their downstream target genes. For example, mice lacking C/EBP alpha die shortly after birth due to severe hypoglycemia and the absence of glycogen storage in liver, whereas knockout of C/EBP beta causes defects in female reproduction. Recombinant protein corresponding to aa270-358 from the bZIP Region of human CDBP alpha, expressed in E.coli. Accession Number: NP_004355 Molecular Weight: ~14.5kD (126 amino acids) Amino Acid Sequence: <MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSM>GAG KAKKSVDKNS NEYRVRRERN NIAVRKSRDK AKQRNVETQQ KVLELTSDND RLRKRVEQLS RELDTLRGIF RQLPESSLVK AMGNCA Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice