C2581-01D

CDR2 (Cerebellar Degeneration-related Protein 2, Paraneoplastic Cerebellar Degeneration-associated Antigen, Major Yo Paraneoplastic Antigen, PCD17)

Size

£685.00

SKU:: C2581-01D
Purity:: Purified.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: CDR2 (NP_001793, 296-405aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Clone:: 4F5
Format:: Supplied as a liquid in PBS, pH 7.2.
Extra Details:: CDR2 (Cerebellar degeneration related protein 2) is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons. Patients with PCD carry a characteristic antibody called anti-Yo. Anti-Yo sera reacts with at least 2 antigens, a major species CDR2, and a minor species CDR1. Applications: Suitable for use in ELISA, Immunofluorescence, and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.