CDR2 (Yo paraneoplastic antigen, cerebellar degeneration-related protein (62kD), cerebellar degeneration-related antigen-2 (62kD), Cerebellar degeneration-related protein 2, Paraneoplastic cerebellar degeneration-associated antigen, Major Yo paraneoplastic antigen)

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£607.00

SKU:: C2581-01
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to the C-terminal region of human CDR2. Species sequence homology: rat (85%)
Format:: Supplied as a liquid in Tris-citrate/phosphate, pH 7-8, containing 0.09% sodium azide.
Extra Details:: Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 Cerebellar degeneration related protein 2) suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism. CDR2 is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons Applications: Suitable for use in Immunohistochemistry and Western Blot. Other Applications not tested. Recommended Dilution: Wester Blot: 2ug/ml; Positive Control: HeLa whole cell lysates. A band is seen at ~51kD. Immunohistochemistry: 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice