C2548-83N2

CD152 (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4) (Biotin)

Size

£492.00

SKU:: C2548-83N2
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Hamster
Clone:: 1B8
Format:: Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with Biotin.
Extra Details:: The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors.1-4 However CD152 is thought to be a negative regulator of T cell activation1-3 and may play a role in apoptotic control of T cells. CD152 exists as a 69kD homodimer1, and is relatively conserved among humans, mice and chickens.2 Applications: • Flow cytometry 1, 2 • Immunoprecipitation 1 • In vitro functional studies 1, 2 • Enhancement of tumor immunity 3 Recommended Dilution: Flow Cytometry: ≤ 3ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.