CD134 Human, IgG2a Fc Mouse, Fusion Protein (OX40)

Size

£735.00

SKU:: C2515-26A
Molecular Weight:: 45.6
Purity:: Purified by size exclusion chromatography.
Storage Conditions:: 4°C Do Not Freeze
Supplier:: United States Biological
Format:: Supplied as a liquid in 50mM Sodium Phosphate pH 7.6, 100mM sodium chloride, 0.5mg/ml Gentamicin Sulfate.
Extra Details:: Human CD134 (OX40) (ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation (2). The CD134 costimulatory pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (5). Blockade of this interaction in mouse abrogated immunological effects in several models of immflamation and rejection (6,7,8,9). CD134-muIg fusion protein binds to CD134L on Human Umbilical Cord Endothelial Cells (HUVEC). Human CD134(OX40)-muIg Fusion Protein* Molecular Structure: A soluble molecule consisting of the extracellular (185 aa) domain of human CD134 fused to the murine IgG2a Fc (232 aa). Predicted monomeric non-glysylated weight is 45.6kD. Fusion construct is dimeric and runs about 105kD in non-reduced SDS-PAGE. Applications: Suitable for use in ELISA, Flow Cytometry. CD134-muIg fusion protein blocks binding of anti-human CD134 to human tumor cells. Other applications not tested. Recommended Dilution Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice