C2445-65C
CD103 (CD103 Antigen, HML-1 Antigen, Human Mucosal Lymphocyte Antigen 1, Huminae, Integrin alpha E, ITGAE, Integrin alpha IEL, MGC141996, Mucosal Lymphocyte 1 Antigen, Mucosal Lymphocyte Antigen 1)
Size
£473.00
- SKU:
- C2445-65C
- Application:
- Flow Cytometry
- Purity:
- Purified
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Hamster
- Immunogen:
- C57BL/6J mouse intestinal intraepithelial lymphocytes
- Clone:
- 2E7
- Format:
- Supplied as a liquid in 100mM BBS, pH 8.2. No preservatives or amine-containing buffer salts added.
- Extra Details:
- CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. This antibody is reported to have signal-inducing activity in a redirected lysis assay and to co-stimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro, which runs counter to the usual inhibition of CTL by anti-integrins. The property of costimulation is not unique to the mouse since the combination of anti-human alphaIEL plus anti-TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated. Applications: Suitable for use in Flow Cytometry. Other applications have not been tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice