C2445-63R
CD103 (Integrin alpha E, Integrin alpha M290, Itgae, Integrin alpha E, Epithelial-associated, alpha-E1, alpha-M290, aM290)
Size
£301.00
- SKU:
- C2445-63R
- Purity:
- Purified by affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Hamster
- Immunogen:
- Mouse intestinal intraepithelial lymphocytes
- Clone:
- 2E7
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
- Extra Details:
- CD103 is a type I transmembrane glycoprotein known as aE integrin or Integrin aIEL chain. It belongs to integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-b stimulation. In association with integrin b7, CD103 is expressed as aE/b7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150kD (C-terminal) chain and a 25kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: ≤1ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice