C2441-90J
CD91 (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)
Size
£800.00
- SKU:
- C2441-90J
- Purity:
- Purified by Protein A affinity chromatography
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Synthetic peptide derived from the human CD91 beta chain.
- Clone:
- 6A34
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
- Extra Details:
- CD91 is also known as alpha 2-Macroglobulin receptor (A2MR), low density lipoprotein receptor-related protein (LRP) or apoliprotein E receptor (APOER). CD91 is a multifunctional cell plasma membrane receptor involved in the process of endocytosis of various ligands that are important in protease and cytokine activity regulation, and lipoprotein metabolism. CD91 expression in breast cancer cell lines T47D2 and BT-201 can be affected by both cell culture density alone and by estrogen. Heat shock proteins appear to be an integral part of the viral life cycle. The heat shock proteins interact with antigenpresenting cells (APC) through CD91 in maturation, activation and representation of foreign peptides with MHC class I molecules on their surface. Expression of CD91 was found increased in individuals, who were infected with HIV-1 for more than 10 years with no evidence of progressive disease. Applications: Suitable for use in Flow Cytometry, ELISA Immunofluorescence/Immunohistochemistry and Western Blot. Other applicaitons have not been tested. Recommended Dilution: Immunofluorescence (IHC Frozen): 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice