C2441-90J-BIOTIN
CD91 (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein) (Biotin)
Size
£1,042.00
- SKU:
- C2441-90J-BIOTIN
- Purity:
- Purified by Protein A affinity chromatography
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Synthetic peptide derived from the human CD91 beta chain.
- Clone:
- 6A34
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Biotin.
- Extra Details:
- CD91 is also known as alpha 2-Macroglobulin receptor (A2MR), low density lipoprotein receptor-related protein (LRP) or apoliprotein E receptor (APOER). CD91 is a multifunctional cell plasma membrane receptor involved in the process of endocytosis of various ligands that are important in protease and cytokine activity regulation, and lipoprotein metabolism. CD91 expression in breast cancer cell lines T47D2 and BT-201 can be affected by both cell culture density alone and by estrogen. Heat shock proteins appear to be an integral part of the viral life cycle. The heat shock proteins interact with antigenpresenting cells (APC) through CD91 in maturation, activation and representation of foreign peptides with MHC class I molecules on their surface. Expression of CD91 was found increased in individuals, who were infected with HIV-1 for more than 10 years with no evidence of progressive disease. Applications: Suitable for use in Flow Cytometry, FLISA, Western Blot and Immunohistochemistry/Immunofluorescence. Other applicaitons have not been tested. Recommended Dilution: Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice