C2441-90-BIOTIN
CD91 (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein) (Biotin)
Size
£869.00
- SKU:
- C2441-90-BIOTIN
- Purity:
- Purified by Protein A affinity chromatography from tissue culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Purified alpha 2 macroglobulin receptor
- Clone:
- 3H1760 (Alpha 2MR alpha-2)
- Format:
- Supplied as a liquid in PBS, pH 7.2. Labeled with Biotin.
- Extra Details:
- CD91, a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2 MR). CD91, also known as Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor or apolipoprotein E receptor. CD91 is a 4525aa protein post translationally cleaved into 3 subunits, a 85kD type I transmembrane carboxyl chain (LRP85) non-covalently bound to a 515kD extracellular N-terminal subunit (LRP515)containing multiple EGF-like and LDL-receptor Class A and Class B domains. Additionally, there is an intracellular domain (LRPICD) which can be cleaved from the transmambrane domain by gamma secretase (May et al. 2004). Clone A2Mr alpha-2 detects an epitope within the LRP515 chain. CD91 is a multifunctional protein involved in processes inluding the phagocytosis and endocytosis of apoptotic cells (Nilsson et al. 2012), clearance of activated serum alpha-2-macroglobulin (Kristensen et al. 1990), modulation of the inflammatory response (Staudt et al. 2013) and acts as a receptor for Pseudomonas aeruginosa exotoxin A (Kounnas et al. 1992). Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, ELISA, Immunoprecipitation, Western Blot and Immunofluorescence. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: Frozen sections Western Blot: Non-reducing conditions Optimal working dilutions to be determined by researcher. Recommended Negative Controls: I1904-78R: IgG1 Murine Negative Control Recommended Positive Control Tissue for IHC: Liver Hybridoma: NS1 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice