C2426-03B
CD71 (Transferrin Receptor, TR, Tfr, TfnrR)
Size
£745.00
- SKU:
- C2426-03B
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Purified ectodomains from human CD71
- Clone:
- 6A513 (3B8 2A1)
- Format:
- Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide
- Extra Details:
- Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95kD. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalized into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:10 Flow Cytometry: 1:10 Immunohistochemistry (Frozen): 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice