C2405-11J

CD51 (Integrin alphaV, Vitronectin alpha Subunit Receptor, VNR)

Size

£338.00

SKU:: C2405-11J
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Cell suspension containing osteoclasts from osteoclastomas
Clone:: 5K274 (13C2)
Format:: Supplied as a liquid in Borate buffered saline, pH 8.2
Extra Details:: CD51 represents the 150kD integrin alphaV chain that associates with integrin beta3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils and platelets. CD51 is the most promiscuous integrin a subunit; it can form heterodimers with the beta1 (CD29), beta3 (CD61), beta5, beta6 and beta8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.1-4 Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry :Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.