C2405-03E
CD49f (Laminin Receptor, Integrin alpha6, VLA alpha6, Platelet gpIc)
Size
£550.00
- SKU:
- C2405-03E
- Purity:
- Purified
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- SW1222 human colorectal cell line
- Clone:
- 5K227 (4F10)
- Format:
- Supplied as a liquid in 100mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.
- Extra Details:
- CD49f is the 125 kDa integrin α6 chain which associates noncovalently with the integrin β1 subunit (CD29) and with the integrin β4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and α6β4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes, and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes, and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Flow Cytometry: ≤ 1ug/10e6 cells Immunohistochemistry: frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice