C2401-02K
CD46 (CD46 Antigen, CD46 Molecule, AHUS2, Antigen Identified by Monoclonal TRA-2-10, Complement Membrane Cofactor Protein, Measles Virus Receptor, Membrane Cofactor Protein Precursor, MCP, MIC10, TLX, TRA2.10, Trophoblast Leukocyte Common Antigen)
Size
£601.00
- SKU:
- C2401-02K
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- HPB-ALL human T cell line
- Clone:
- MEM-258
- Format:
- Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
- Extra Details:
- CD46, also designated membrane cofactor protein, is a 45-70kD protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). Applications: Suitable for use in Western Blot, Immunoprecipitation and Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1ug/ml Western Blot: non-reducing conditions Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice