C2394-04A3
CD41 (Integrin alpha IIb chain, gpIIb-IIIa, Platelet Membrane gpIIb-IIIa Complex)
Size
£812.00
- SKU:
- C2394-04A3
- Purity:
- Purified by Protein G affinity chromatography from hybridoma culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rat
- Immunogen:
- Recombinant protein corresponding to Leu32-Arg988 from mouse CD41, expressed in CHO cells.
- Clone:
- 7H181
- Format:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- Integrin alpha 2b, (ITGA2b) also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114kD and 22kD) during transit through the Golgi. ITGA2b associates with integrin beta3 to form complexes that interact with fibrinogen, von Willebrand factor, fibronectin, and vitronectin. ITGA2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, mouse ITGA2b shares 81% human and 89% rat aa sequence identity. Applications: Suitable for use in ELISA, Flow Cytometry, and Immunocytochemistry. Other applications have not been tested. Recommended Dilutions: Flow Cytometry: 0.25ug/10e6 cells using mouse platelets. Immunocytochemistry: 8-25ug/ml for immersion fixed mouse platelets and immersion fixed mouse bone marrow cells Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice